NATOoperativeJacquesKristoffissummonedintoaction,onhisbirthday,totrackdownGalinaKonstantin,whohasscamperedoffwithanextremelyvaluableanddangeroustop-secretcargo.FindingGalinadoesn'ttakelong,andJacquesmustwrapupthemissionbyreturningGalinaandthecontrabandtohissuperiorsbytrain.Jacques'sphysicianwifeMadelineisn'thappyaboutthisturnofevents.Butsheseeshimoffatthetrainstationwiththecouple'steenagedaughterBaileyKristoffandsonEthanKristoff.Galina'sill-gottengainisthreevialsofSP-43,anultra-virulentstrainofsmallpox,culturedinfluorescentgreenserumthatcontainsseveralotherpathogens.Agroupofterrorists,ledbyMasonCole,intendtohijackthetrainandstealthevirusfortheirownends.ButstandingintheirwayisJacques.Thevirusendsupgettinglooseinthetrain'sventilationsystem.Unfortunately,Jacques'sfamilypickedthismomenttosurprisehimforhisbirthdaybysecretlytaggingalongfortheride.Jacquesbecomesaone-manarmyashefightstoprotecthisfamilyandtheotherpassengers,andstopColeandhisfollowers本条目为2002年拍摄的Derailed，与2005年的一部同名电影出现混淆问题（2005年版本见），请大家正确收藏。----豆瓣团队